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Submit ReviewSubstance P
说明： Sensory neuropeptide; inflammatory mediator
纯度： ≥95% (HPLC)
生物活性 for Substance P
Substance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
技术数据 for Substance P
| 分子量 | 1347.6 |
| 公式 | C63H98N18O13S |
| 序列 |
RPKPQQFFGLM (Modifications: Met-11 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 33507-63-0 |
| PubChem ID | 36511 |
| InChI Key | ADNPLDHMAVUMIW-CUZNLEPHSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Substance P
| 溶解性 | Soluble to 0.80 mg/ml in water |
产品说明书 for Substance P
参考文献 for Substance P
参考文献是支持产品生物活性的出版物。
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370
Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85 PMID: 6196797
Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689
Merck Index 12 9032
If you know of a relevant reference for Substance P, please let us know.
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关键词: Substance P, Substance P supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Other, 1156, Tocris Bioscience
15 篇 Substance P 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Substance P 的部分引用包括：
Wease and Davies (2005) Substance P selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID: 16305744
Kowtharapu et al (2018) Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing. Int J Mol Sci 19 PMID: 29401709
Frara et al (2018) Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes. Connect Tissue Res 59 30 PMID: 28399671
Chen et al (2014) μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience 267 67 PMID: 24583035
Shanley et al (2011) Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neurosci 8 10 PMID: 21294877
Fisher et al (2015) Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37 PMID: 25617052
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717
Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID: 30598641
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
Wan et al (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID: 28119567
Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553 PMID: 24381506
Hanson et al (2009) A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment. Antioxid Redox Signal 14 798 PMID: 19531663
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci 29 15551 PMID: 20007479
Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID: 24310605
Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons. J Biomol Screen 24 10103 PMID: 15537880
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