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说明： Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
化学名： (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
纯度： ≥99% (HPLC)
生物活性 for Sulindac
Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.
技术数据 for Sulindac
| 分子量 | 356.41 |
| 公式 | C20H17FO3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 38194-50-2 |
| PubChem ID | 1548887 |
| InChI Key | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| Smiles | FC1=CC=C(/C(C(C)=C3CC(O)=O)=C\C2=CC=C(S(C)=O)C=C2)C3=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Sulindac
参考文献 for Sulindac
参考文献是支持产品生物活性的出版物。
Haanen (2001) Sulindac and its derivatives: a novel class of anticancer agents. Curr.Opin.Investig.Drugs 2 677 PMID: 11569947
Shen and Winter (1977) Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 12 90 PMID: 343530
Taylor et al (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 60 6607 PMID: 11118042
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关键词: Sulindac, Sulindac supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, 1707, Tocris Bioscience
1 篇 Sulindac 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Sulindac 的部分引用包括：
Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84 PMID: 25679284
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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