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说明： High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
化学名： 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
纯度： ≥98% (HPLC)
生物活性 for SW 033291
SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.
化合物库 for SW 033291
SW 033291 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SW 033291
| 分子量 | 412.59 |
| 公式 | C21H20N2OS3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 459147-39-8 |
| PubChem ID | 3337839 |
| InChI Key | LCYAYKSMOVLVRL-UHFFFAOYSA-N |
| Smiles | NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SW 033291
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.26 | 100 | |
| ethanol | 8.25 | 20 |
制备储备液 for SW 033291
以下数据基于产品分子量 412.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.85 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for SW 033291
参考文献 for SW 033291
参考文献是支持产品生物活性的出版物。
Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857
If you know of a relevant reference for SW 033291, please let us know.
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关键词: SW 033291, SW 033291 supplier, SW033291, 15-PGDH, hydroxyprostaglandin, dehydrogenase, inhibitors, inhibits, hematopoiesis, hematopoietic, hepatocyte, proliferation, PGE2, haematopoietic, stem, cells, HSC, Other, Dehydrogenases, Stem, Cell, Proliferation, Hematopoietic, Cells, 5759, Tocris Bioscience
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