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Submit ReviewAn effective non-competitive NMDA receptor antagonist in vivo and in vitro; may bind to more than one site, one of which is the polyamine site.
分子量 | 354.47 |
公式 | C12H28N6.H2SO4 |
储存 | Store at RT |
CAS Number | 182285-12-7 |
PubChem ID | 66977 |
InChI Key | OZZMUVKANAPKGI-UHFFFAOYSA-N |
Smiles | OS(O)(=O)=O.NC(=N)NCCCCCCCCCCNC(N)=N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Reynolds et al (1991) 1,10-Bis(guanidino)decane inhibits N-MthD.-aspartate responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 259 626 PMID: 1658306
Reynolds (1992) Interactions between zinc and spermidine on the N-MthD.-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentam. J.Pharmacol.Exp.Ther. 263 632 PMID: 1432693
关键词: Synthalin sulfate, Synthalin sulfate supplier, Non-competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0635, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.