T 0156 hydrochloride

Name: T 0156 hydrochloride
Brand: Tocris Bioscience
SKU: 1676

Cat. No. 1676 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1676 has been discontinued.

View all Phosphodiesterases products.

说明： Highly potent, selective PDE5 inhibitor

化学名： 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for T 0156 hydrochloride

T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC₅₀ values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC₅₀ > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

许可信息

Sold with the permission of Tanabe Seiyaku Co. Ltd.

技术数据 for T 0156 hydrochloride

分子量	620.06
公式	C₃₁H₂₉N₅O₇.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	324572-93-2
PubChem ID	9852041
InChI Key	RBJCBXAXUHCWBR-UHFFFAOYSA-N
Smiles	Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for T 0156 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for T 0156 hydrochloride

参考文献是支持产品生物活性的出版物。

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152

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关键词: T 0156 hydrochloride, T 0156 hydrochloride supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, 1676, Tocris Bioscience

1 篇 T 0156 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 T 0156 hydrochloride 的部分引用包括：

Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977 PMID: 25404319