T 0901317

Cat. No. 2373 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent liver X receptor (LXR) agonist; also CAR inverse agonist

化学名： N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide

纯度： ≥98% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for T 0901317

T 0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC₅₀ ~ 50 nM, K_d values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC₅₀ of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

化合物库 for T 0901317

T 0901317 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for T 0901317

分子量	481.33
公式	C₁₇H₁₂F₉NO₃S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	293754-55-9
PubChem ID	447912
InChI Key	SGIWFELWJPNFDH-UHFFFAOYSA-N
Smiles	OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for T 0901317

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	48.13	100
	ethanol	48.13	100

制备储备液 for T 0901317

以下数据基于产品分子量 481.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.78 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for T 0901317

分析证书/产品说明书

化学品安全技术说明书

参考文献 for T 0901317

参考文献是支持产品生物活性的出版物。

Repa et al (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524 PMID: 10968783

Koldamova et al (2005) The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J.Biol.Chem. 280 4079 PMID: 15557325

Houck et al (2004) T0901317 is a dual LXR/FXR agonist. Mol.Gen.Metab. 83 184

Mitro et al (2007) The nuclear receptor LXR is a glucose sensor. Nature Lett. 445 219

Kanno et al (2013) T0901317, a potent LXR agonist, is an inverse agonist of CAR. J.Toxicol.Sci. 38 309 PMID: 23665929

If you know of a relevant reference for T 0901317, please let us know.

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关键词: T 0901317, T 0901317 supplier, Potent, liver, X, receptor, LXR, agonists, FXR, Receptors, Liver, Farnesoid, LXR-like, T0901317, Constitutive, Androstane, Receptor, 2373, Tocris Bioscience