主页 / 细胞生物学 / Signal Transduction / Cytokine and NF-κB Signaling / AP-1 / AP-1 Inhibitors / T 5224

T 5224

Cat. No. 7317 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective inhibitor of c-Fos/activator protein (AP)-1
化学名： 5-[4-(Cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]benzenepropanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for T 5224

T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.

技术数据 for T 5224

分子量 517.53
公式 C29H27NO8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 530141-72-1
PubChem ID 23626877
InChI Key DALCQQSLNPLQFZ-UHFFFAOYSA-N
Smiles O=C(O)CCC1=CC(=CC=C1OCC2=CC=C3C(=O)NOC3=C2)C(=O)C4=CC=C(OC5CCCC5)C=C4O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for T 5224

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.75 100

制备储备液 for T 5224

以下数据基于产品分子量 517.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for T 5224

参考文献是支持产品生物活性的出版物。

Tsuchida et al (2006) Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J.Med.Chem 49 80 PMID: 16392794

Aikawa et al (2008) Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat.Biotechnol 26 817 PMID: 18587386

If you know of a relevant reference for T 5224, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 AP-1 Inhibitors

关键词: T 5224, T 5224 supplier, T5224, selective, inhibitor, inhibits, inhibitors, cfos, c-Fos, c-Fos/activator, protein, (AP)-1, AP1, collagen, indiced, arthritis, anti-inflammatory, AP-1, 7317, Tocris Bioscience

篇 T 5224 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 T 5224 的引用文献。 您是否知道使用了 Tocris T 5224 的优秀论文？ 请告知我们.

T 5224 的评论

目前没有该产品的评论。 Be the first to review T 5224 and earn rewards!

Have you used T 5224?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review