T-peptide

Name: T-peptide
Brand: Tocris Bioscience
SKU: 6726

Cat. No. 6726 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6726 has been discontinued.

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说明： Cytotoxic Tau peptide; cell permeable

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for T-peptide

T-peptide is a peptide derived from microtubule binding repeat of Tau protein. Self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. Cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. Co-localizes with pathological hyperphosphorylated forms of tau in vitro. Cell permeable.

技术数据 for T-peptide

分子量	2195.66
公式	C₉₂H₁₇₁N₄₅O₁₈
序列	VQIVYKRRRRRRRRR (Modifications: Val-1 = N-terminal Ac, Val-1 = D-Val, Gln-2 = D-Gln, Ile-3 = D-Ile, Val-4 = D-Val, Tyr-5 = D-Tyr, Lys-6 = D-Lys, Arg-15 = C-terminal amide)
储存	Store at -20°C
CAS Number	2022956-62-1
Smiles	[H]N([C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for T-peptide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for T-peptide

参考文献是支持产品生物活性的出版物。

Zhao et al (2010) Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. J.Neurosci.Res. 88 3399 PMID: 20882568

Veloria et al (2017) Novel cell model for tauopathy induced by a cell-permeable tau-related peptide ACS.Chem.Neurosci. 8 2734 PMID: 28837764

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关键词: T-peptide, T-peptide supplier, Microtubules, 6726, Tocris Bioscience

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