Tabimorelin hemifumarate

Cat. No. 2308 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, orally active ghrelin receptor agonist

别名： NN 703

化学名： N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide hemifumarate

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tabimorelin hemifumarate

Tabimorelin hemifumarate is a potent, orally active ghrelin receptor (GHS-R1a) agonist (K_i = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC₅₀ value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats.

技术数据 for Tabimorelin hemifumarate

分子量	586.73
公式	C₃₂H₄₀N₄O₃.½C₄H₄O₄
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	242143-80-2
PubChem ID	11981159
InChI Key	YQDJPWXYLLPOPW-LWTUVRFUSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N.CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tabimorelin hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	5.29	10 温和加热
	DMSO	58.67	100

制备储备液 for Tabimorelin hemifumarate

以下数据基于产品分子量 586.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.7 mL	8.52 mL	17.04 mL
5 mM	0.34 mL	1.7 mL	3.41 mL
10 mM	0.17 mL	0.85 mL	1.7 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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产品说明书 for Tabimorelin hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tabimorelin hemifumarate

参考文献是支持产品生物活性的出版物。

Hansen et al (1999) Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur.J.Endocrinol. 141 180 PMID: 10427162

Holm et al (2004) Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Eur.J.Pharmacol. 150 893 PMID: 15191361

If you know of a relevant reference for Tabimorelin hemifumarate, please let us know.

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关键词: Tabimorelin hemifumarate, Tabimorelin hemifumarate supplier, Potent, orally, active, ghrelin, receptor, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, NN703, NN, 703, Ghrelin, 2308, Tocris Bioscience

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