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TAK 165

Cat. No. 3599 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective ErbB2 inhibitor
别名： Mubritinib
化学名： 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TAK 165

TAK 165 is a potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.

技术数据 for TAK 165

分子量 468.47
公式 C25H23F3N4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 366017-09-6
PubChem ID 6444692
InChI Key ZTFBIUXIQYRUNT-MDWZMJQESA-N
Smiles FC(C(C=C2)=CC=C2/C=C/C1=NC(COC3=CC=C(CCCCN4C=CN=N4)C=C3)=CO1)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAK 165

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.14 75

制备储备液 for TAK 165

以下数据基于产品分子量 468.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 2.85 mL 14.23 mL 28.46 mL
3.75 mM 0.57 mL 2.85 mL 5.69 mL
7.5 mM 0.28 mL 1.42 mL 2.85 mL
37.5 mM 0.06 mL 0.28 mL 0.57 mL

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产品说明书 for TAK 165

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TAK 165

参考文献是支持产品生物活性的出版物。

Sridhar et al (2003) Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4 397 PMID: 12850190

Nagasawa et al (2006) Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int.J.Urol. 13 585 PMID: 16771730

Spector et al (2007) Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res. 9 205

If you know of a relevant reference for TAK 165, please let us know.

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关键词: TAK 165, TAK 165 supplier, Potent, selective, ErbB2, inhibitors, inhibits, Epidermal, Growth, Factor, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, TAK165, Mubritinib, 3599, Tocris Bioscience

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