TAK 21d

Cat. No. 5209 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent FAAH inhibitor

化学名： 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAK 21d

TAK 21d is a potent FAAH inhibitor; (IC₅₀ values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.

技术数据 for TAK 21d

分子量	397.38
公式	C₁₉H₁₇F₂N₇O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1143578-94-2
PubChem ID	57749996
InChI Key	JCWVFSJNIBAGQN-UHFFFAOYSA-N
Smiles	FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAK 21d

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	3.97	10
	1eq. HCl	7.95	20

制备储备液 for TAK 21d

以下数据基于产品分子量 397.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	12.58 mL	62.91 mL	125.82 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
2 mM	1.26 mL	6.29 mL	12.58 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

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产品说明书 for TAK 21d

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAK 21d

参考文献是支持产品生物活性的出版物。

Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468 PMID: 24440478

If you know of a relevant reference for TAK 21d, please let us know.

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关键词: TAK 21d, TAK 21d supplier, TAK21d, potent, inhibitors, inhibits, fatty, acid, amide, hydrolase, FAAH, neuropathic, inflammatory, pain, analgesic, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 5209, Tocris Bioscience

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