TAK 779

Cat. No. 4340 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CCR5 and CCR2 chemokine receptor antagonist

化学名： N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAK 779

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC₅₀ values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC₅₀ = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

技术数据 for TAK 779

分子量	531.13
公式	C₃₃H₃₉N₂O₂.Cl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	229005-80-5
PubChem ID	183789
InChI Key	VDALIBWXVQVFGZ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C2=CC(C=C(C(NC3=CC=C(C[N+](C)(C)C4CCOCC4)C=C3)=O)CCC5)=C5C=C2)C=C1.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAK 779

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	5.31	10
	DMSO	2.66	5

制备储备液 for TAK 779

以下数据基于产品分子量 531.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	18.83 mL	94.14 mL	188.28 mL
0.5 mM	3.77 mL	18.83 mL	37.66 mL
1 mM	1.88 mL	9.41 mL	18.83 mL
5 mM	0.38 mL	1.88 mL	3.77 mL

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产品说明书 for TAK 779

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAK 779

参考文献是支持产品生物活性的出版物。

Baba et al (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 96 5698 PMID: 10318947

Suzaki et al (2008) A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 31 783 PMID: 18094012

Takami et al (2002) TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 22 780 PMID: 12142563

If you know of a relevant reference for TAK 779, please let us know.

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关键词: TAK 779, TAK 779 supplier, TAK779, potent, selective, chemokines, receptors, antagonists, CCR5, CCR2, macrophage, viral, replication, ischemia, asthma, Chemokine, CC, Receptors, HIV, 4340, Tocris Bioscience

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