Tamoxifen

Name: Tamoxifen
Brand: Tocris Bioscience
SKU: 6342
Rating: 5 (1 reviews)

Cat. No. 6342 8 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Estrogen receptor partial agonist/antagonist

化学名： 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine

纯度： ≥98% (HPLC)

说明书

引用文献 (8)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tamoxifen

Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

化合物库 for Tamoxifen

Tamoxifen is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Tamoxifen

分子量	371.51
公式	C₂₆H₂₉NO
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	10540-29-1
PubChem ID	2733526
InChI Key	NKANXQFJJICGDU-QPLCGJKRSA-N
Smiles	CN(C)CCOC1=CC=C(C=C1)/C(C2=CC=CC=C2)=C(CC)\C3=CC=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tamoxifen

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	37.15	100
	DMSO	7.43	20

制备储备液 for Tamoxifen

以下数据基于产品分子量 371.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for Tamoxifen

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tamoxifen

参考文献是支持产品生物活性的出版物。

Jordan et al (2003) Tamoxifen: a most unlikely pioneering medicine. Nat.Rev.Drug Discov. 2 203 PMID: 12612646

If you know of a relevant reference for Tamoxifen, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: Tamoxifen, Tamoxifen supplier, SERM, selective, estrogen, receptor, modulators, antagonists, antagonism, partial, agonists, agonism, anticancer, chemotherapeutic, Estrogen, and, Related, Receptors, 6342, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Tamoxifen and its salts, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

8 篇 Tamoxifen 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tamoxifen 的部分引用包括：

Alison L et al (2019) Rapid Plasticity of Higher-Order Thalamocortical Inputs during Sensory Learning. Neuron 103 277-291.e4 PMID: 31151774

Paul L et al (2017) Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity. Front Pharmacol 7 503 PMID: 28066250

Silva et al (2019) Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment. Biomolecules 9 PMID: 31434290

Ya-Jing et al (2023) Metabotropic glutamate receptor 5-mediated inhibition of inward-rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice. J Neurosci Res 101 1170-1187 PMID: 36807930

Laurie et al (2020) A homogeneous bioluminescent immunoassay to probe cellular signaling pathway regulation. Commun Biol 3 8 PMID: 31909200

Susana et al (2020) Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer. Cancer Cell 38 516-533.e9 PMID: 32976773

Rachael et al (2020) ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat Genet 52 187-197 PMID: 31913353

Ying et al (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. J Biomed Sci 19 80 PMID: 22931352

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Tamoxifen 的评论

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Tamoxifen for ERT-cre mice.

By Anonymous on 05/23/2019

分析类型： In Vivo

种属： Mouse

given for tamoxifen-inducible cre mice. saw excellent GFP expression with 2 doses.

given 180mg/kg/day i.p., injections 24 hours apart. dissolved 30mg/ml in 1:9 etoh and sunflower seed oil

Pathways for Tamoxifen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.