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Tamsulosin hydrochloride

Cat. No. 3050 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective α1A antagonist
化学名： 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tamsulosin hydrochloride

Tamsulosin hydrochloride is a selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligible effect on mean arterial blood pressure in vivo.

化合物库 for Tamsulosin hydrochloride

Tamsulosin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Tamsulosin hydrochloride

分子量 444.97
公式 C20H28N2O5S.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 106463-17-6
PubChem ID 5362376
InChI Key ZZIZZTHXZRDOFM-XFULWGLBSA-N
Smiles C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tamsulosin hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 4.45 10
DMSO 44.5 100

制备储备液 for Tamsulosin hydrochloride

以下数据基于产品分子量 444.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.24 mL 22.47 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for Tamsulosin hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Tamsulosin hydrochloride

参考文献是支持产品生物活性的出版物。

Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID: 7781702

Taguchi et al (1997) Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID: 8996174

Ohtake et al (2005) Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345 PMID: 16536901

If you know of a relevant reference for Tamsulosin hydrochloride, please let us know.

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关键词: Tamsulosin hydrochloride, Tamsulosin hydrochloride supplier, Selective, α1A-adrenoceptor, alpha1A-adrenoceptor, a1a-adrenoceptor, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, antagonists, Receptors, Adrenergic, Alpha-1, 3050, Tocris Bioscience

3 篇 Tamsulosin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tamsulosin hydrochloride 的部分引用包括：

Kunit et al (2014) Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate. Am J Physiol Renal Physiol 307 F823 PMID: 25056351

Xiao et al (2019) Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system. Commun Biol 2 33 PMID: 30701198

Trevisani et al (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol 145 1123 PMID: 15937520

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Tamsulosin hydrochloride 的评论

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Used to investigate cell metabolism.
By Anonymous on 01/27/2023
分析类型： In Vitro
种属： Rat
细胞系/组织： Primary hippocampal neurons

The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.

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