Tariquidar dihydrochloride

Cat. No. 5757 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent P-glycoprotein (P-gp) inhibitor

化学名： N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tariquidar dihydrochloride

Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC₅₀ = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.

化合物库 for Tariquidar dihydrochloride

Tariquidar dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Tariquidar dihydrochloride

分子量	719.66
公式	C₃₈H₃₈N₄O₆.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1992047-62-7
PubChem ID	121513890
InChI Key	ZJCJRGRTDKIFJJ-UHFFFAOYSA-N
Smiles	O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tariquidar dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	35.98	50

制备储备液 for Tariquidar dihydrochloride

以下数据基于产品分子量 719.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.9 mL	27.79 mL
2.5 mM	0.56 mL	2.78 mL	5.56 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

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产品说明书 for Tariquidar dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tariquidar dihydrochloride

参考文献是支持产品生物活性的出版物。

Kannan et al (2011) The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2 82 PMID: 22778859

Loo et al (2015) Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 290 29389 PMID: 26507655

If you know of a relevant reference for Tariquidar dihydrochloride, please let us know.

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关键词: Tariquidar dihydrochloride, Tariquidar dihydrochloride supplier, Potent, P-glycoprotein, P-gp, inhibitors, inhibits, multidrug, resistance, MDR, breast, cancer, resistant, protein, BCRP, substrates, cytotoxic, abcb1, atp, binding, cassette, 206873-63-4, Multidrug, Transporters, 5757, Tocris Bioscience

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