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Tasimelteon

Cat. No. 7493 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective dual melatonin receptor (MT1/MT2) agonist
化学名： N-[[(1R,2R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tasimelteon

Tasimelteon is a high affinity and selective dual melatonin receptor (MT1/MT2) agonist (Ki values are 0.304 nM and 0.0692 nM, respectively). It has no significant interaction with any other commonly screened receptors or enzyme binding sites. Tasimelteon induces a potent, concentration-dependent inhibition of forskolin-stimulated cAMP accumulation in NIH-3T3 cells stably expressing human MT1 (EC50 = 0.74 nM) or expressing human MT2 (EC50 = 0.1 nM) receptors. Tasimelteon is a circadian regulator.

技术数据 for Tasimelteon

分子量 245.32
公式 C15H19NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 609799-22-6
PubChem ID 10220503
InChI Key PTOIAAWZLUQTIO-GXFFZTMASA-N
Smiles CCC(NC[C@@H]1C[C@H]1C2=C(CCO3)C3=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tasimelteon

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.53 100
ethanol 24.53 100

制备储备液 for Tasimelteon

以下数据基于产品分子量 245.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.08 mL 20.38 mL 40.76 mL
5 mM 0.82 mL 4.08 mL 8.15 mL
10 mM 0.41 mL 2.04 mL 4.08 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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参考文献 for Tasimelteon

参考文献是支持产品生物活性的出版物。

Lavedan et al (2015) Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology 91 142 PMID: 25534555

Vachharajani et al (2003) Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist. J.Pharm.Sci. 92 760 PMID: 12661062

If you know of a relevant reference for Tasimelteon, please let us know.

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关键词: Tasimelteon, Tasimelteon supplier, Potent, selective, dual, melatonin, receptors, MT1, MT2, agonists, circadian, rhythm, regulators, Melatonin, (MT), Receptors, 7493, Tocris Bioscience

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