TAT-PDHPS1

Cat. No. 7832 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： YAP inhibitor

纯度： ≥95% (HPLC)

文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAT-PDHPS1

TAT-PDHPS1 is a YAP inhibitor (Yes-associated protein inhibitor). It comprises the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), which activates protein phosphatase 2A (PP2A). This activation leads to the phosphorylation of YAP and the suppression of YAP-targeted genes. TAT-PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro and ovarian tumor growth in a subcutaneous xenograft mouse model.

技术数据 for TAT-PDHPS1

分子量	3744.32
公式	C₁₅₆H₂₈₀N₆₂O₄₅
序列	GRKKRRQRRRPPQQIATTTASAATAAAIGATPRAK
储存	Store at -20°C
纯度	≥95% (HPLC)
InChI Key	NNCYONQIMWXOHL-MRKNDOTPSA-N
Smiles	O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAT-PDHPS1

溶解性	Soluble to 2 mg/ml in water

产品说明书 for TAT-PDHPS1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAT-PDHPS1

参考文献是支持产品生物活性的出版物。

Pan et al (2022) Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling. Mol.Cancer Ther. 21 1160 PMID: 35545004

If you know of a relevant reference for TAT-PDHPS1, please let us know.

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关键词: TAT-PDHPS1, TAT-PDHPS1 supplier, Peptide, deregulated, in, hypertrophic, scar-1, PDHPS1, PDHPS1-TAT, YAP, PTPA, PP2A, yap, inhibitor, yes, associated, protein, Hippo/Yap, signaling, 7832, Tocris Bioscience

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Pathways for TAT-PDHPS1