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Discontinued Product
2669 has been discontinued.
说明： High affinity σ1 ligand
化学名： (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
纯度： ≥99% (HPLC)
生物活性 for TC 1
TC 1 is a high affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
化合物库 for TC 1
TC 1 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for TC 1
| 分子量 | 297.37 |
| 公式 | C19H20FNO |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 362512-81-0 |
| PubChem ID | 10040286 |
| InChI Key | FYGREZKTJIXWIH-UHFFFAOYSA-N |
| Smiles | OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC 1
参考文献 for TC 1
参考文献是支持产品生物活性的出版物。
Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074
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关键词: TC 1, TC 1 supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Sigma1, 2669, Tocris Bioscience
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