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TC-E 5001

Cat. No. 5049 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5049 has been discontinued.

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说明： Potent tankyrase inhibitor
化学名： 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TC-E 5001

TC-E 5001 is a dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.

技术数据 for TC-E 5001

分子量 409.46
公式 C20H19N5O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 865565-29-3
PubChem ID 16013184
InChI Key LQZSHPITKSPDLC-UHFFFAOYSA-N
Smiles CC1=NN=C(SCC3=NC(C4=CC=C(OC)C=C4)=NO3)N1C2=CC=C(OC)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC-E 5001

参考文献是支持产品生物活性的出版物。

Shultz et al (2012) [1,2,4]Triazole-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127 PMID: 22260203

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关键词: TC-E 5001, TC-E 5001 supplier, TC-E5001, TNKS1, TNKS2, tankyrase, inhibitors, inhibits, wnt, signaling, signalling, Poly(ADP-ribose), Polymerase, Tankyrase, 5049, Tocris Bioscience

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