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Submit ReviewTC-E 5003
Discontinued Product
5099 has been discontinued.
View all Protein Arginine Methyltransferases products.
说明： Selective PRMT1 inhibitor
化学名： N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
纯度： ≥98% (HPLC)
生物活性 for TC-E 5003
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
技术数据 for TC-E 5003
| 分子量 | 401.26 |
| 公式 | C16H14Cl2N2O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 17328-16-4 |
| PubChem ID | 87052 |
| InChI Key | SHRCVZJKZJGIHQ-UHFFFAOYSA-N |
| Smiles | O=C(CCl)NC(C=C2)=CC=C2S(C1=CC=C(NC(CCl)=O)C=C1)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC-E 5003
参考文献 for TC-E 5003
参考文献是支持产品生物活性的出版物。
Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717 PMID: 21440447
关键词: TC-E 5003, TC-E 5003 supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5099, Tocris Bioscience
1 篇 TC-E 5003 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TC-E 5003 的部分引用包括：
Min-Jung et al (2020) TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. FEBS Lett 594 2923-2930 PMID: 32767856
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.