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TC-I 2000

Cat. No. 4632 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： TRPM8 blocker
化学名： N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-I 2000

TC-I 2000 is a tRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).

化合物库 for TC-I 2000

TC-I 2000 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-I 2000

分子量 414.4
公式 C23H18F4N2O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1159996-20-9
PubChem ID 57326210
InChI Key ADCDUDFEGFKKQH-UHFFFAOYSA-N
Smiles O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-I 2000

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.44 100
ethanol 8.29 20

制备储备液 for TC-I 2000

以下数据基于产品分子量 414.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for TC-I 2000

参考文献是支持产品生物活性的出版物。

Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507

If you know of a relevant reference for TC-I 2000, please let us know.

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关键词: TC-I 2000, TC-I 2000 supplier, TCI2000, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 4632, Tocris Bioscience

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