主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPM Channels / TRPM Channel Antagonists / TC-I 2014

TC-I 2014

Cat. No. 5410 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent TRPM8 antagonist
化学名： 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-I 2014

TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.

化合物库 for TC-I 2014

TC-I 2014 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-I 2014

分子量 467.41
公式 C23H19F6N3O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1221349-53-6
PubChem ID 45274257
InChI Key GZINXHRSQAMEQY-ZZEZOPTASA-N
Smiles FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-I 2014

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.74 100
ethanol 46.74 100

制备储备液 for TC-I 2014

以下数据基于产品分子量 467.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.7 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for TC-I 2014

参考文献是支持产品生物活性的出版物。

Parks et al (2011) Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 54 233 PMID: 21128593

If you know of a relevant reference for TC-I 2014, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPM Channel Antagonists

关键词: TC-I 2014, TC-I 2014 supplier, TC-I2014, TRPM8, antagonist, TRPM, 5410, Tocris Bioscience

1 篇 TC-I 2014 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-I 2014 的部分引用包括：

Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702

您是否知道使用了 Tocris TC-I 2014 的优秀论文？ 请告知我们.

TC-I 2014 的评论

目前没有该产品的评论。 Be the first to review TC-I 2014 and earn rewards!

Have you used TC-I 2014?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review