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TC-MCH 7c

Cat. No. 4365 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist
化学名： 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
纯度： ≥97% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-MCH 7c

TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.

技术数据 for TC-MCH 7c

分子量 408.47
公式 C24H25FN2O3
储存 Store at RT
纯度 ≥97% (HPLC)
CAS Number 864756-35-4
PubChem ID 11654412
InChI Key ANCFKYJMXNMYNZ-UHFFFAOYSA-N
Smiles O=C1C=C(OCC3=CC=C(F)C=C3)C=CN1C2=CC=C(OCCN4CCCC4)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-MCH 7c

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 40.85 100
DMSO 20.42 50

制备储备液 for TC-MCH 7c

以下数据基于产品分子量 408.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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产品说明书 for TC-MCH 7c

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for TC-MCH 7c

参考文献是支持产品生物活性的出版物。

Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883 PMID: 21190859

Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77 PMID: 19836369

If you know of a relevant reference for TC-MCH 7c, please let us know.

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关键词: TC-MCH 7c, TC-MCH 7c supplier, TCMCH7c, obese, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormones, receptors, Melanin-concentrating, Hormone, Receptors, 4365, Tocris Bioscience

2 篇 TC-MCH 7c 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-MCH 7c 的部分引用包括：

Hi-Joon et al (2019) Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. Mol Neurobiol 56 2408-2423 PMID: 30030752

Hi-Joon et al (2020) Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents. Exp Neurobiol 29 453-469 PMID: 33372169

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