TCS 1102

Pricing Availability   Qty
说明: Potent, dual orexin receptor antagonist
化学名: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
纯度: ≥98% (HPLC)
说明书
引用文献 (7)
评论
文献 (1)

生物活性 for TCS 1102

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.

许可信息

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

技术数据 for TCS 1102

分子量 470.59
公式 C27H26N4O2S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 916141-36-1
PubChem ID 11960895
InChI Key YSBGRVXJEMSEQY-DEOSSOPVSA-N
Smiles O=C(CSC2=NC(C=CC=C5)=C5N2C)N1CCC[C@H]1[C@](NC3=CC=CC=C3C4=CC=CC=C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS 1102

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.06 100
ethanol 47.06 100

制备储备液 for TCS 1102

以下数据基于产品分子量 470.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.62 mL 21.25 mL
5 mM 0.42 mL 2.12 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for TCS 1102

分析证书/产品说明书
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参考文献 for TCS 1102

参考文献是支持产品生物活性的出版物。

Winrow et al (2010) Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 58 185 PMID: 19596018

Bergman et al (2008) Proline bis-amides as potent dual orexin receptor antagonists. Bioorg.Med.Chem.Letts 18 1425

Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 12 e0173967 PMID: 28296947


If you know of a relevant reference for TCS 1102, please let us know.

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查看全部 Non-selective Orexin Antagonists

关键词: TCS 1102, TCS 1102 supplier, TCS1102, orexin, receptors, OX1, OX2, antagonists, non-selective, dual, potent, merck, Non-selective, Orexin, 3818, Tocris Bioscience

7 篇 TCS 1102 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TCS 1102 的部分引用包括:

Korim et al (2014) Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation. Diabetes 63 1895 PMID: 24550189

Yu et al (2023) Circadian regulation of developmental synaptogenesis via the hypocretinergic system. Nat Commun 14 3195 PMID: 37268623

Daniel J et al (2021) Orexin Modulation of VTA Dopamine Neuron Activity: Relevance to Schizophrenia. Int J Neuropsychopharmacol 24 344-353 PMID: 33587746

Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One PMID: 28296947


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该领域的文献

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