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Submit ReviewTCS 2210
说明： Inducer of neuronal differentiation in MSCs
化学名： 1,2-Dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
生物活性 for TCS 2210
TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity.
化合物库 for TCS 2210
TCS 2210 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for TCS 2210
| 分子量 | 323.35 |
| 公式 | C18H17N3O3 |
| 储存 | Store at -20°C |
| CAS Number | 1201916-31-5 |
| PubChem ID | 44607172 |
| InChI Key | ZOFZKGFBKISZRI-UHFFFAOYSA-N |
| Smiles | O=C(NO)C3=CC1=C(C=C3)NC(C(CCCC2=CC=CC=C2)=N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 2210
参考文献 for TCS 2210
参考文献是支持产品生物活性的出版物。
Kim et al (2009) Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J.Med.Chem. 52 7931 PMID: 20014867
关键词: TCS 2210, TCS 2210 supplier, TCS2210, neuronal, inducers, differentiation, mesenchymal, stem, cells, MSC, induces, Mesenchymal, Stem, Cells, Neural, 3877, Tocris Bioscience
2 篇 TCS 2210 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS 2210 的部分引用包括：
Moshfegh et al (2016) A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. PLoS One 6 25104 PMID: 27157261
Utta et al (2015) Orbital Fibroblasts From Graves' Orbitopathy Patients Share Functional and Immunophenotypic Properties With Mesenchymal Stem/Stromal Cells. Invest Ophthalmol Vis Sci 56 6549-57 PMID: 26457540
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
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Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.