TCS 2314

Cat. No. 3900 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： α₄β₁ (VLA-4) antagonist

化学名： 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TCS 2314

TCS 2314 is an integrin very late antigen-4 (VLA-4; α₄β₁) antagonist (IC₅₀ = 4.4 nM). Blocks the activation of inflammatory cells.

化合物库 for TCS 2314

TCS 2314 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS 2314

分子量	522.59
公式	C₂₈H₃₄N₄O₆
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	317353-73-4
PubChem ID	11226207
InChI Key	ITXAAOWFOURIHK-DEOSSOPVSA-N
Smiles	O=C(N2CCOC[C@H]2[C@@](N3CCC(CC(O)=O)CC3)=O)CC1=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS 2314

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	52.26	100
	ethanol	26.13	50

制备储备液 for TCS 2314

以下数据基于产品分子量 522.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.57 mL	19.14 mL
5 mM	0.38 mL	1.91 mL	3.83 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for TCS 2314

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TCS 2314

参考文献是支持产品生物活性的出版物。

Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440

If you know of a relevant reference for TCS 2314, please let us know.

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关键词: TCS 2314, TCS 2314 supplier, TCS2314, VLA-4, antagonist, very, late, antigen, 4, antagonists, integrin, α4β1, Integrins, Cell, Adhesion, Molecules, 3900, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

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The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.