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Submit ReviewTCS 2510
说明： Selective EP4 agonist
化学名： (5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone
纯度： ≥98% (HPLC)
生物活性 for TCS 2510
TCS 2510 is a highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.
技术数据 for TCS 2510
| 分子量 | 383.49 |
| 公式 | C21H29N5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 346673-06-1 |
| PubChem ID | 9864831 |
| InChI Key | JWYPJSNXPZTEHL-VJKINUSGSA-N |
| Smiles | O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@H](CC3=CC=CC=C3)O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TCS 2510
| 溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
产品说明书 for TCS 2510
参考文献 for TCS 2510
参考文献是支持产品生物活性的出版物。
Billot et al (2003) Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg.Med.Chem.Lett. 130 1129
If you know of a relevant reference for TCS 2510, please let us know.
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关键词: TCS 2510, TCS 2510 supplier, TCS2510, ep4, prostanoid, receptors, selective, agonists, Prostanoid, Receptors, 4069, Tocris Bioscience
2 篇 TCS 2510 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS 2510 的部分引用包括：
Liu et al (2012) Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol 303 F1425 PMID: 22933297
Tzu-Ming et al (2020) Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis. J Pharmacol Exp Ther 375 357-366 PMID: 32848074
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