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TCS 359

Cat. No. 2591 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent FLT3 inhibitor
化学名： 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TCS 359

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

技术数据 for TCS 359

分子量 360.43
公式 C18H20N2O4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 301305-73-7
PubChem ID 1048845
InChI Key FSPQCTGGIANIJZ-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS 359

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.81 30

制备储备液 for TCS 359

以下数据基于产品分子量 360.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.3 mM 9.25 mL 46.24 mL 92.48 mL
1.5 mM 1.85 mL 9.25 mL 18.5 mL
3 mM 0.92 mL 4.62 mL 9.25 mL
15 mM 0.18 mL 0.92 mL 1.85 mL

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参考文献 for TCS 359

参考文献是支持产品生物活性的出版物。

Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282 PMID: 16580199

If you know of a relevant reference for TCS 359, please let us know.

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关键词: TCS 359, TCS 359 supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, 2591, Tocris Bioscience

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