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TCS 5861528

Cat. No. 3938 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3938 has been discontinued.

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说明： TRPA1 blocker
化学名： 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for TCS 5861528

TCS 5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

化合物库 for TCS 5861528

TCS 5861528 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS 5861528

分子量 369.42
公式 C19H23N5O3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 332117-28-9
PubChem ID 2873523
InChI Key ZUTUWJYMCADJHD-UHFFFAOYSA-N
Smiles O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TCS 5861528

参考文献是支持产品生物活性的出版物。

Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147 PMID: 19512877

Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578 PMID: 20004676

Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 479 253 PMID: 20566388

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关键词: TCS 5861528, TCS 5861528 supplier, Selective, TRPA1, blockers, antagonists, Channels, Transient, Receptor, Potential, HC030031, TCS5861528, 3938, Tocris Bioscience

1 篇 TCS 5861528 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TCS 5861528 的部分引用包括：

Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340

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