TCS JNK 5a

Cat. No. 2827 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of JNK2 and JNK3

化学名： N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

纯度： ≥99% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TCS JNK 5a

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC₅₀ values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC₅₀ < 5.0).

化合物库 for TCS JNK 5a

TCS JNK 5a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS JNK 5a

分子量	332.42
公式	C₂₀H₁₆N₂OS
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	312917-14-9
PubChem ID	766949
InChI Key	WQGDQGAFSDMBLA-UHFFFAOYSA-N
Smiles	O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS JNK 5a

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	33.24	100

制备储备液 for TCS JNK 5a

以下数据基于产品分子量 332.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.04 mL	30.08 mL
5 mM	0.6 mL	3.01 mL	6.02 mL
10 mM	0.3 mL	1.5 mL	3.01 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for TCS JNK 5a

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TCS JNK 5a

参考文献是支持产品生物活性的出版物。

Angell et al (2007) N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 17 1296 PMID: 17194588

If you know of a relevant reference for TCS JNK 5a, please let us know.

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关键词: TCS JNK 5a, TCS JNK 5a supplier, Selective, inhibitors, inhibits, JNK2, JNK3, Mitogen-Activated, Protein, Kinases, MAPK, c-Jun, N-Terminal, SAPKs, Stress-Activated, TCSJNK5a, JNK/c-jun, 2827, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TCS JNK 5a

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.