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Submit ReviewtcY-NH2
说明： Selective PAR4 antagonist
别名： (trans-Cinnamoyl)-YPGKF-NH2
纯度： ≥95% (HPLC)
生物活性 for tcY-NH2
tcY-NH2 is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
技术数据 for tcY-NH2
| 分子量 | 739.87 |
| 公式 | C40H49N7O7 |
| 序列 |
YPGKF (Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 327177-34-4 |
| PubChem ID | 11479675 |
| InChI Key | XKRAKQXQVIGYQC-PHOSSJRVSA-N |
| Smiles | NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for tcY-NH2
参考文献 for tcY-NH2
参考文献是支持产品生物活性的出版物。
Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701 PMID: 11606309
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关键词: tcY-NH2, tcY-NH2 supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, (trans-Cinnamoyl)-YPGKF-NH2, 1488, Tocris Bioscience
4 篇 tcY-NH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 tcY-NH2 的部分引用包括：
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Chen et al (2022) Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor. Cell Death Discov. 8 189 PMID: 35399122
Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Redox Biol 34 346 PMID: 24469043
Carrim et al (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Br J Cancer 6 640 PMID: 26569550
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