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TDI 11861

Cat. No. 8036 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Soluble adenylyl cyclase inhibitor
化学名： (3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TDI 11861

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC50 values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; Kd = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC50 = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

许可信息

Sold under license from Cornell University

技术数据 for TDI 11861

分子量 494.93
公式 C22H25ClF2N6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2857049-72-8
PubChem ID 166101565
InChI Key XVGSKZXXLKUEIO-MRXNPFEDSA-N
Smiles FC(F)N1N=C(C2=NC(N)=NC(Cl)=C2)C(CC3=C(C=CC=C3)OCCN4[C@@H](COCC4)CO)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TDI 11861

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.49 100
ethanol 49.49 100

制备储备液 for TDI 11861

以下数据基于产品分子量 494.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Reconstitution Calculator

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参考文献 for TDI 11861

参考文献是支持产品生物活性的出版物。

Miller et al (2022) Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 65 15208 PMID: 36346696

Balbach et al (2023) On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 14 637 PMID: 36788210

If you know of a relevant reference for TDI 11861, please let us know.

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关键词: TDI 11861, TDI 11861 supplier, TDI11861, soluble, adenylyl, cyclase, inhibitor, inhibitors, inhibits, sAC, potent, selective, cell, permeable, Adenylyl, Cyclase, 8036, Tocris Bioscience

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