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Teijin compound 1

Cat. No. 3664 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent CCR2b antagonist
化学名： N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Teijin compound 1

Teijin compound 1 is a potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).

技术数据 for Teijin compound 1

分子量 476.32
公式 C21H21ClF3N3O2.HCl
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 1313730-14-1
PubChem ID 56972239
InChI Key PGUQBBISBKGQDC-GMUIIQOCSA-N
Smiles O=C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)N[C@@H]1CCN(CC2=CC=C(Cl)C=C2)C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Teijin compound 1

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参考文献 for Teijin compound 1

参考文献是支持产品生物活性的出版物。

Hall et al (2009) Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol.Pharmacol. 75 1325 PMID: 19297521

Moree et al (2004) Small molecule antagonists of the CCR2b receptor. Part 2: discovery process and initial structure-activity relationships of diamine derivatives. Bioorg.Med.Chem.Letts. 14 5413

Moree et al (2008) Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg.Med.Chem.Letts. 18 1869

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关键词: Teijin compound 1, Teijin compound 1 supplier, Potent, CCR2b, antagonists, chemokines, receptors, Teijin, compound1, Chemokine, CC, Receptors, 3664, Tocris Bioscience

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