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Tenofovir

Cat. No. 3666 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Reverse transcriptase inhibitor
别名： PMPA,(R)-9-(2-Phosphonoylmethoxypropyl)adenine
化学名： (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tenofovir

Tenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

技术数据 for Tenofovir

分子量 287.21
公式 C9H14N5O4P
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 147127-20-6
PubChem ID 464205
InChI Key SGOIRFVFHAKUTI-ZCFIWIBFSA-N
Smiles C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tenofovir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1.1eq. NaOH 28.72 100
DMSO 2.87 10

制备储备液 for Tenofovir

以下数据基于产品分子量 287.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.41 mL 34.82 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for Tenofovir

参考文献是支持产品生物活性的出版物。

Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197 PMID: 7502044

Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586 PMID: 8913470

Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250 PMID: 9765248

If you know of a relevant reference for Tenofovir, please let us know.

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关键词: Tenofovir, Tenofovir supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine, DNA, HIV, 3666, Tocris Bioscience

1 篇 Tenofovir 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tenofovir 的部分引用包括：

Joseph V et al (2023) ATP/ADP biosensor organoids for drug nephrotoxicity assessment. Front Cell Dev Biol 11 1138504 PMID: 36936695

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Tenofovir 的评论

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Study of in vivo tenofovir breakdown.
By Anonymous on 12/24/2019
分析类型： In Vivo
种属： Mouse

We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.

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