Terbinafine hydrochloride

Cat. No. 6484 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective K_2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

化学名： N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Terbinafine hydrochloride

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

技术数据 for Terbinafine hydrochloride

分子量	327.89
公式	C₂₁H₂₅N.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	78628-80-5
PubChem ID	5282481
InChI Key	BWMISRWJRUSYEX-SZKNIZGXSA-N
Smiles	CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Terbinafine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	32.79	100
	water	3.28	10 温和加热

制备储备液 for Terbinafine hydrochloride

以下数据基于产品分子量 327.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.25 mL	30.5 mL
5 mM	0.61 mL	3.05 mL	6.1 mL
10 mM	0.3 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

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产品说明书 for Terbinafine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Terbinafine hydrochloride

参考文献是支持产品生物活性的出版物。

Petranyi et al (1984) Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239 PMID: 6547247

Wright et al (2017) Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 493 444 PMID: 28882594

If you know of a relevant reference for Terbinafine hydrochloride, please let us know.

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关键词: Terbinafine hydrochloride, Terbinafine hydrochloride supplier, K2P, selective, TASK3, activators, activates, squalene, epoxidase, monooxygenase, inhibitors, inhibits, antifungal, antimycotic, Two-P, Potassium, Channels, Other, Oxygenases/Oxidases, Antifungals, 6484, Tocris Bioscience

1 篇 Terbinafine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Terbinafine hydrochloride 的部分引用包括：

Richard L et al (2021) Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy. Sleep 44 PMID: 32745213

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