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Submit ReviewTeriflunomide
说明： Inhibitor of DHODH; active metabolite of Leflunomide
别名： A77 1726
化学名： 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
纯度： ≥99% (HPLC)
生物活性 for Teriflunomide
Teriflunomide is an inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Immunosuppressive agent. Active metabolite of leflunomide.
化合物库 for Teriflunomide
Teriflunomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Teriflunomide
| 分子量 | 270.21 |
| 公式 | C12H9F3N2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 108605-62-5 |
| PubChem ID | 54684141 |
| InChI Key | UTNUDOFZCWSZMS-YFHOEESVSA-N |
| Smiles | O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Teriflunomide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.02 | 100 |
制备储备液 for Teriflunomide
以下数据基于产品分子量 270.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.7 mL | 18.5 mL | 37.01 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.7 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for Teriflunomide
参考文献 for Teriflunomide
参考文献是支持产品生物活性的出版物。
Williamson et al (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 270 22467 PMID: 7673235
Davis et al (1996) The immunosuppressive metabolite of leflun. is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35 1270 PMID: 8573583
Iglesias-Bregna et al (2013) Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 347 203 PMID: 23892570
If you know of a relevant reference for Teriflunomide, please let us know.
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关键词: Teriflunomide, Teriflunomide supplier, Active, metabolite, leflunomide, A771726, A, 77-1726, 771226, A77, 1726, dihydroorolate, dehydrogenase, inhibitors, inhibits, immunosuppressive, agent, drug, immunomodulatory, Immunosuppressants, Dihyroorotate, Dehydrogenase, DNA,, RNA, and, Protein, Synthesis, 5069, Tocris Bioscience
2 篇 Teriflunomide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Teriflunomide 的部分引用包括：
Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779
Takashi et al (2022) Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models. Cell Rep 38 110268 PMID: 35045289
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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