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Submit ReviewTetrodotoxin citrate
说明： Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
别名： TTx citrate
化学名： (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate
纯度： ≥98% (HPLC)
生物活性 for Tetrodotoxin citrate
Tetrodotoxin citrate, the water-soluble citrate salt of tetrodotoxin, is a reversible, potent, selective and high affinity inhibitor of voltage gated sodium channels Nav 1.6, 1.1, 1.3, 1.4, 1.2 and 1.7 (IC50 values are 2.3 nM, 4.1 nM, 5.3 nM, 7.6 nM, 14 nM and 36 nM, respectively). Binding is reversible and high affinity (Kd = 1-10 nM). Tetrodotoxin shows antagonism of aconitine-induced cardiac toxicity, analgesic effects in mouse models of neuropathy and prolonged duration of local anesthesia in animals when combined with capsaicin. Tetrodotoxin also shows pH-dependent blockade of canine cardiac L-type Ca2+ (Cav1.x) channels, blocks primary reward in an animal study of drug-seeking lever pressing.
Tetrodotoxin (Cat. No. 1078) also available.
技术数据 for Tetrodotoxin citrate
| 分子量 | 319.27 |
| 公式 | C11H17N3O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 18660-81-6 |
| PubChem ID | 16759596 |
| InChI Key | CFMYXEVWODSLAX-CKYAAQHSSA-N |
| Smiles | OC1(CO)[C@H](O4)C(O)[C@@]2([C@@H]([C@@H](O)N3)C1O[C@](O)4[C@H]2O)NC3=N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tetrodotoxin citrate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.93 | 100 |
制备储备液 for Tetrodotoxin citrate
以下数据基于产品分子量 319.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for Tetrodotoxin citrate
参考文献 for Tetrodotoxin citrate
参考文献是支持产品生物活性的出版物。
Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35 1743 PMID: 9076753
Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117 PMID: 5032475
Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52 PMID: 2434008
Merck Index 12 9382
Grimm and See (2000) Dissociation of primary and secondary reward-relevant limbic nuclei in an animal model of relapse. Neuropsychopharmacology 22 473 PMID: 10731622
Hegyi et al (2013) Tetrodotoxin blockade on canine cardiac L-type Ca2+ channels depends on pH and redox potential. Mar.Drugs 11 2140 PMID: 23771047
Ono et al (2013) Antagonistic effects of tetrodotoxin on aconitine-induced cardiac toxicity. J.Nippon Med.Sch. 80 350 PMID: 24189353
Tsukamoto et al (2017) Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav1.1 to Nav1.7). Br.J.Pharmacol. 174 3881 PMID: 28832970
Shoromony et al (2019) Prolonged duration local anesthesia by combined delivery of capsaicin- and tetrodotoxin-loaded liposomes. Anesth.Analg. 129 709 PMID: 31425210
If you know of a relevant reference for Tetrodotoxin citrate, please let us know.
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关键词: Tetrodotoxin citrate, Tetrodotoxin citrate supplier, Citrate, salt, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, TTx, citrate, Voltage-gated, 1069, Tocris Bioscience
74 篇 Tetrodotoxin citrate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tetrodotoxin citrate 的部分引用包括：
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Filter by:
homeostatic plasticity.
By
Vineet Arora on 11/19/2020
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Organotypic cultures
For studying homeostatic plasticity
Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By
Anonymous on 02/03/2020
分析类型： In Vivo
种属： Mouse
10uM TTX
blocks calcium oscillations well.
By
Karthik krishnamurthy on 11/08/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： hippocampal neurons
used to block calcium oscillations in neurons
20 nM was used
