Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTFLLR-NH2
说明： PAR1-activating peptide
纯度： ≥95% (HPLC)
生物活性 for TFLLR-NH2
TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.
Control Peptide also available.
技术数据 for TFLLR-NH2
| 分子量 | 647.82 |
| 公式 | C31H53N9O6 |
| 序列 |
TFLLR (Modification: Arg-5 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 197794-83-5 |
| PubChem ID | 10146183 |
| InChI Key | ANAMCEKSRDPIPX-GFGQVAFXSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TFLLR-NH2
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for TFLLR-NH2
参考文献 for TFLLR-NH2
参考文献是支持产品生物活性的出版物。
de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506
Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351
Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174
If you know of a relevant reference for TFLLR-NH2, please let us know.
按产品操作查看相关产品
关键词: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience
11 篇 TFLLR-NH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TFLLR-NH2 的部分引用包括：
Zhang et al (2019) Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing. J Tissue Eng 10 2041731418820030 PMID: 30728936
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Zhang et al (2017) PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep 15 2595 PMID: 28447716
Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241
Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131
Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226
Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049
Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. J Neuroinflammation 5 ra26 PMID: 22472648
Chen et al (2012) Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation. Endocrinology 9 142 PMID: 22731117
Müller et al (2018) Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β. Curr Biol 28 3481 PMID: 30415704
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236
您是否知道使用了 Tocris TFLLR-NH2 的优秀论文？ 请告知我们.
TFLLR-NH2 的评论
目前没有该产品的评论。 Be the first to review TFLLR-NH2 and earn rewards!
Have you used TFLLR-NH2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image