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Submit ReviewTG 4-155
说明： High affinity and selective EP2 receptor antagonist
化学名： (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
纯度： ≥98% (HPLC)
生物活性 for TG 4-155
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
技术数据 for TG 4-155
| 分子量 | 394.46 |
| 公式 | C23H26N2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1164462-05-8 |
| PubChem ID | 5886965 |
| InChI Key | YBHUXHFZLMFETJ-MDZDMXLPSA-N |
| Smiles | CC2=CC1=CC=CC=C1N2CCNC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TG 4-155
参考文献 for TG 4-155
参考文献是支持产品生物活性的出版物。
Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657
Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506
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关键词: TG 4-155, TG 4-155 supplier, TG4-155, high, affinity, selective, EP2, prostanoid, receptors, antagonists, Prostanoid, Receptors, 5052, Tocris Bioscience
2 篇 TG 4-155 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TG 4-155 的部分引用包括：
Cuesto et al (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS One 10 e0118475 PMID: 25764078
Donna A et al (2020) Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells. Front Immunol 11 143 PMID: 32158443
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