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TGN 020

Cat. No. 5425 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Aquaporin 4 (AQP4) channel blocker
化学名： N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TGN 020

TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

化合物库 for TGN 020

TGN 020 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TGN 020

分子量 206.22
公式 C8H6N4OS
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 51987-99-6
PubChem ID 4173511
InChI Key AGEGZHOPKZFKBP-UHFFFAOYSA-N
Smiles O=C(NC1=NN=CS1)C2=CN=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TGN 020

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.12 20

制备储备液 for TGN 020

以下数据基于产品分子量 206.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 24.25 mL 121.23 mL 242.46 mL
1 mM 4.85 mL 24.25 mL 48.49 mL
2 mM 2.42 mL 12.12 mL 24.25 mL
10 mM 0.48 mL 2.42 mL 4.85 mL

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产品说明书 for TGN 020

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TGN 020

参考文献是支持产品生物活性的出版物。

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629

If you know of a relevant reference for TGN 020, please let us know.

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关键词: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience

2 篇 TGN 020 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TGN 020 的部分引用包括：

Wang et al (2017) Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1. J Biol Chem 292 8291 PMID: 28360106

Harrison et al (2020) Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain 143 2576 PMID: 32705145

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