TH 5427 hydrochloride

Cat. No. 6534 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent NUDT5 inhibitor

化学名： 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TH 5427 hydrochloride

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC₅₀ = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

许可信息

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

化合物库 for TH 5427 hydrochloride

TH 5427 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TH 5427 hydrochloride

分子量	527.79
公式	C₂₀H₂₀Cl₂N₈O₃.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	2253744-57-7
PubChem ID	137919865
Smiles	O=C1N(C)C(C(N(CC2=NN=C(C3=CC(Cl)=C(Cl)C=C3)O2)C(N4CCNCC4)=N5)=C5N1C)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TH 5427 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	5.28	10
	DMSO	10.56	20

制备储备液 for TH 5427 hydrochloride

以下数据基于产品分子量 527.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	9.47 mL	47.37 mL	94.73 mL
1 mM	1.89 mL	9.47 mL	18.95 mL
2 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.19 mL	0.95 mL	1.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for TH 5427 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TH 5427 hydrochloride

参考文献是支持产品生物活性的出版物。

Page et al (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 9 250 PMID: 29343827

If you know of a relevant reference for TH 5427 hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Hydrolase Inhibitors

关键词: TH 5427 hydrochloride, TH 5427 hydrochloride supplier, TH5427, HCl, nudix, hydrolase, 5, inhibitors, inhibits, potent, selective, NUDT5, breast, cancer, proliferation, Other, Hydrolases, 6534, Tocris Bioscience

篇 TH 5427 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TH 5427 hydrochloride 的引用文献。您是否知道使用了 Tocris TH 5427 hydrochloride 的优秀论文？请告知我们.