主页 / 药理学 / GPCRs / 7-TM Receptors / Dopamine Receptors / Non-selective Dopamine / Non-selective Dopamine Antagonists / Thioridazine hydrochloride

Thioridazine hydrochloride

Cat. No. 3070 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dopamine receptor antagonist; antipsychotic
化学名： 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Thioridazine hydrochloride

Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

技术数据 for Thioridazine hydrochloride

分子量 407.04
公式 C21H26N2S2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 130-61-0
PubChem ID 66062
InChI Key NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Thioridazine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 30.53 75
DMSO 40.7 100

制备储备液 for Thioridazine hydrochloride

以下数据基于产品分子量 407.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.28 mL 24.57 mL
5 mM 0.49 mL 2.46 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Thioridazine hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Thioridazine hydrochloride

参考文献是支持产品生物活性的出版物。

Merck Index 13 9435

Sachlos et al (2012) Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761

Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505

If you know of a relevant reference for Thioridazine hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Non-selective Dopamine Antagonists

关键词: Thioridazine hydrochloride, Thioridazine hydrochloride supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Cancer, Stem, Cells, Cell, Differentiation, 3070, Tocris Bioscience

1 篇 Thioridazine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Thioridazine hydrochloride 的部分引用包括：

Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455 PMID: 21131351

您是否知道使用了 Tocris Thioridazine hydrochloride 的优秀论文？ 请告知我们.

Thioridazine hydrochloride 的评论

目前没有该产品的评论。 Be the first to review Thioridazine hydrochloride and earn rewards!

Have you used Thioridazine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.