THIQ

Name: THIQ
Brand: Tocris Bioscience
SKU: 3032
Rating: 5 (1 reviews)

Cat. No. 3032 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective MC₄ receptor agonist

化学名： N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

纯度： ≥95% (HPLC)

说明书

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for THIQ

THIQ is a potent and selective melanocortin 4 (MC₄) receptor agonist (IC₅₀ values are 1.2, 761 and 2067 nM for human MC₄, MC₃ and MC₁ receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

技术数据 for THIQ

分子量	589.17
公式	C₃₃H₄₁ClN₆O₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	312637-48-2
PubChem ID	9938402
InChI Key	HLCHESOMJVGDSJ-LOYHVIPDSA-N
Smiles	O=[C@@]([C@H](NC([C@H]5CC(C=CC=C6)=C6CN5)=O)CC4=CC=C(Cl)C=C4)N1CCC(CN2N=CN=C2)(C3CCCCC3)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for THIQ

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.89	10

制备储备液 for THIQ

以下数据基于产品分子量 589.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	16.97 mL	84.87 mL	169.73 mL
0.5 mM	3.39 mL	16.97 mL	33.95 mL
1 mM	1.7 mL	8.49 mL	16.97 mL
5 mM	0.34 mL	1.7 mL	3.39 mL

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产品说明书 for THIQ

分析证书/产品说明书

化学品安全技术说明书

参考文献 for THIQ

参考文献是支持产品生物活性的出版物。

Sebhat et al (2002) Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocorti J.Med.Chem. 45 4589 PMID: 12361385

Martin et al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71 PMID: 12409007

Mutulis et al (2004) New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J.Med.Chem. 47 4613 PMID: 15317471

If you know of a relevant reference for THIQ, please let us know.

按标靶查看相关产品

关键词: THIQ, THIQ supplier, Potent, selective, MC4R, receptors, agonists, Melanocortin, Receptors, 3032, Tocris Bioscience

3 篇 THIQ 的引用文献

引用文献是使用了 Tocris 产品的出版物。 THIQ 的部分引用包括：

Garfield et al (2015) A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci 18 863 PMID: 25915476

Sohn et al (2013) Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Int J Biol Sci 152 612 PMID: 23374353

Huang and Tao (2014) A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants. Front Pharmacol 10 817 PMID: 25076858

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THIQ 的评论

平均评分: 5 (Based on 1 Review.)

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THIQ treatment increase social interactions.

By Anonymous on 01/11/2019

分析类型： In Vivo

种属： Mouse

Recently, we demonstrated that the deletion of the NFKB1 gene, which encodes the p50 NF-kappa B subunit, causes impairment in social behaviours, with reductions in social interactions in mice. In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. THIQ treatment increased social interactions both in wild type and p50-/- mice. In particular, after treatment with THIQ, p50-/- mice showed a prosocial behaviour analogous to that of basal WT mice.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.