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Submit ReviewThymosin β4
说明： Potent actin polymerization regulator
生物活性 for Thymosin β4
Thymosin β4 is a naturally occuring, potent regulator of actin polymerization present in human platelets at a concentration of 200 - 500 μM. Sequesters G-actin monomers in a 1:1 ratio (Kd = 0.7 - 1.0 μM) and allows rapid filament polymerization in the presence of profilin. Implicated in wound healing, induction of MMPs, chemotaxis, angiogenesis, inflammatory processes and tumor progression.
技术数据 for Thymosin β4
| 分子量 | 4963.49 |
| 公式 | C212H350N56O78S |
| 序列 |
SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (Modifications: Ser-1 = N-terminal Ac) |
| 储存 | Store at -20°C |
| CAS Number | 77591-33-4 |
| PubChem ID | 90488838 |
| InChI Key | QBEAMNLSDYIUGM-SIQRNXPUSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Thymosin β4
参考文献 for Thymosin β4
参考文献是支持产品生物活性的出版物。
Yu et al (1993) Thymosin β10 and thymosin β4 are both actin monomer sequestering proteins. J.Biol.Chem. 268 502 PMID: 8416954
Huff et al (2001) β-thymosins, small acidic peptides with multiple functions. Int.J.Biochem.Cell Biol. 33 205 PMID: 11311852
Smart et al (2007) Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis 10 229 PMID: 17632766
关键词: Thymosin b4, Thymosin b4 supplier, Potent, actin, polymerization, regulator, Thymosin, β4, beta4, Thymosinβ4, Thymosinb4, polymerisation, Actin, 3390, Tocris Bioscience
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