Tiotropium bromide

Cat. No. 5902 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent muscarinic receptor antagonist

别名： Ba 679 BR

化学名： (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0^2,4]nonane bromide

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tiotropium bromide

Tiotropium bromide is a potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC₅₀ = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

化合物库 for Tiotropium bromide

Tiotropium bromide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Tiotropium bromide

分子量	472.42
公式	C₁₉H₂₂BrNO₄S₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	136310-93-5
PubChem ID	5487426
InChI Key	DQHNAVOVODVIMG-RGECMCKFSA-M
Smiles	C[N+]1(C)[C@]2([H])[C@H]3[C@H](O3)[C@@]1([H])C[C@@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tiotropium bromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	9.45	20
	DMSO	47.24	100

制备储备液 for Tiotropium bromide

以下数据基于产品分子量 472.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.17 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for Tiotropium bromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tiotropium bromide

参考文献是支持产品生物活性的出版物。

Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640 PMID: 7952627

Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303 PMID: 24307202

Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr. J.Pharm.Sci. 115 374 PMID: 21358117

If you know of a relevant reference for Tiotropium bromide, please let us know.

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关键词: Tiotropium bromide, Tiotropium bromide supplier, Ba679BR, potent, muscarinic, receptors, antagonists, M1, M2, M3, M4, Ba, 679, BR, Non-selective, Muscarinics, 5902, Tocris Bioscience

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