Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTipifarnib
说明： Potent farnesyltransferase inhibitor; orally bioavailable
化学名： 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
纯度： ≥98% (HPLC)
生物活性 for Tipifarnib
Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.
技术数据 for Tipifarnib
| 分子量 | 489.4 |
| 公式 | C27H22Cl2N4O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 192185-72-1 |
| PubChem ID | 159324 |
| InChI Key | PLHJCIYEEKOWNM-HHHXNRCGSA-N |
| Smiles | CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tipifarnib
参考文献 for Tipifarnib
参考文献是支持产品生物活性的出版物。
End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150
按产品操作查看相关产品
关键词: Tipifarnib, Tipifarnib supplier, Potent, farnesyltransferase, inhibitors, inhibits, antitumor, cell, penetrant, orally, bioavailable, Protein, Prenyltransferases, Post-translational, Modifications, 6410, Tocris Bioscience
Tipifarnib 的评论
目前没有该产品的评论。 Be the first to review Tipifarnib and earn rewards!
Have you used Tipifarnib?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image