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Submit ReviewTizanidine hydrochloride
说明： α2 agonist
化学名： 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Tizanidine hydrochloride
Tizanidine hydrochloride is an α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.
化合物库 for Tizanidine hydrochloride
Tizanidine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Tizanidine hydrochloride
| 分子量 | 290.17 |
| 公式 | C9H8ClN5S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 64461-82-1 |
| PubChem ID | 114869 |
| InChI Key | ZWUKMNZJRDGCTQ-UHFFFAOYSA-N |
| Smiles | ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tizanidine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 29.02 | 100 | |
| DMSO | 29.02 | 100 |
制备储备液 for Tizanidine hydrochloride
以下数据基于产品分子量 290.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.45 mL | 17.23 mL | 34.46 mL |
| 5 mM | 0.69 mL | 3.45 mL | 6.89 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.45 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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产品说明书 for Tizanidine hydrochloride
参考文献 for Tizanidine hydrochloride
参考文献是支持产品生物活性的出版物。
Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329
Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925
If you know of a relevant reference for Tizanidine hydrochloride, please let us know.
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关键词: Tizanidine hydrochloride, Tizanidine hydrochloride supplier, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, Receptors, Adrenergic, Alpha-2, 3609, Tocris Bioscience
1 篇 Tizanidine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tizanidine hydrochloride 的部分引用包括：
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.