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Submit ReviewTL 13-110
说明： Negative control for TL 13-112 (Cat. No. 6745)
化学名： N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
纯度： ≥98% (HPLC)
生物活性 for TL 13-110
TL 13-110 is a negative control for TL 13-112 (Cat. No. 6745). Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).
许可信息
Sold under license from Dana-Farber Cancer Institute
技术数据 for TL 13-110
| 分子量 | 988.59 |
| 公式 | C49H62ClN9O9S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2229037-09-4 |
| Smiles | CC(C)OC1=CC(C2CCN(CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C5CCCNC5=O)C4=O)=O)=O)CC2)=C(C)C=C1NC6=NC=C(Cl)C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TL 13-110
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 49.43 | 50 |
制备储备液 for TL 13-110
以下数据基于产品分子量 988.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.02 mL | 10.12 mL | 20.23 mL |
| 2.5 mM | 0.4 mL | 2.02 mL | 4.05 mL |
| 5 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 25 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for TL 13-110
参考文献 for TL 13-110
参考文献是支持产品生物活性的出版物。
Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase. J.Med.Chem. 61 4249 PMID: 29660984
If you know of a relevant reference for TL 13-110, please let us know.
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关键词: TL 13-110, TL 13-110 supplier, TL13-110, PROTACS, PROTAC, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, ALK, inhibitors, degraders, negative, controls, TPD, protein, degradation, Negative, Controls, 6746, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia