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TL4-12

Cat. No. 5910 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent MAP4K2 (GCK) inhibitor
化学名： 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TL4-12

TL4-12 is a potent MAP4K2 (GCK) inhibitor (IC50 = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50 = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.

许可信息

Sold under license from Dana-Farber Cancer Institute.

化合物库 for TL4-12

TL4-12 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TL4-12

分子量 500.53
公式 C25H27F3N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1620820-12-3
PubChem ID 134812827
InChI Key HXKJJIMUMNPQQY-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(C)C(OC2=CC(NC)=NC=N2)=C1)NC3=CC(N4CCN(C)CC4)=CC(C(F)(F)F)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TL4-12

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.01 20
1eq. HCl 10.01 20

制备储备液 for TL4-12

以下数据基于产品分子量 500.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.99 mL 49.95 mL 99.89 mL
1 mM 2 mL 9.99 mL 19.98 mL
2 mM 1 mL 4.99 mL 9.99 mL
10 mM 0.2 mL 1 mL 2 mL

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参考文献 for TL4-12

参考文献是支持产品生物活性的出版物。

Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183 PMID: 25075558

If you know of a relevant reference for TL4-12, please let us know.

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关键词: TL4-12, TL4-12 supplier, MAP4K2, inhibitors, inhibits, mitogen, activated, protein, kinase, potent, Other, MAPK, 5910, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.