TM2 TEAD inhibitor

Cat. No. 7917 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

化学名： 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide

纯度： ≥98% (HPLC)

文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TM2 TEAD inhibitor

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC₅₀ = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

技术数据 for TM2 TEAD inhibitor

分子量	435.57
公式	C₂₆H₃₃N₃O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1008768-41-9
PubChem ID	68301145
InChI Key	LWLAYULJAJMPKG-UHFFFAOYSA-N
Smiles	O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TM2 TEAD inhibitor

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	43.56	100
	ethanol	43.56	100

制备储备液 for TM2 TEAD inhibitor

以下数据基于产品分子量 435.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.3 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.3 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.3 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for TM2 TEAD inhibitor

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TM2 TEAD inhibitor

参考文献是支持产品生物活性的出版物。

Hu et al (2022) Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. eLife 11 e80210 PMID: 36398861

If you know of a relevant reference for TM2 TEAD inhibitor, please let us know.

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关键词: TM2 TEAD inhibitor, TM2 TEAD inhibitor supplier, TM2TEAD, TM2, TEAD, potent, reversible, inhibitors, inhibits, transcription, factor, antiproliferation, liver, organoids, growth, TEAD-YAP, TEA, domain, palmitoylation, ex, vivo, YAP, hippo, TEAD2, TEAD4, Hippo/Yap, signaling, Other, Transcription, Factors, Organoids, 7917, Tocris Bioscience

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